Impact of liposomal delivery on coenzyme Q10 absorption: a double-blind, placebo-controlled, randomized trial

In a randomized, double-blind, placebo-controlled, crossover study, 18 men and women ingested a single dose of placebo, 100 mg of non-liposomal CoQ10, or 100 mg of LipoVantage® Liposomal CoQ10. Venous blood samples were collected and analyzed for plasma CoQ10 concentrations. Results showed that LipoVantage® Liposomal CoQ10 had significantly higher Cmax (+31.3%, p < 0.001) and AUC0-24 (+22.6%, p < 0.001) values as compared to non-liposomal CoQ10. The conclusion: Liposomal delivery significantly enhances CoQ-10 absorption.

Jäger, R., Purpura, M., Godavarthi, A., Ceylan, H. I., Balcombe, S. T., Chandrappa, A., & Tinsley, G. M. (2025). Impact of liposomal delivery on coenzyme Q10 absorption: A double-blind, placebo-controlled, randomized trial. Frontiers in Nutrition, 12, 1605033. https://doi.org/10.3389/fnut.2025.1605033