Effects of Ginger Supplementation on Markers of Inflammation and Functional Capacity in Individuals with Mild to Moderate Joint Pain 

Performed at the Exercise & Sport Nutrition Laboratory at Texas A&M University

In a randomized, placebo-controlled, parallel-arm study, 30 men and women with a history of mild to severe joint and muscle pain, as well as inflammation, provided blood samples, completed questionnaires, rated their pain, and performed physical tests before and after receiving either 125 mg/day of GingerT3® Ginger Extract or a placebo. Results showed that ginger supplementation reduced perceptions of muscle pain, improved ratings of pain, stiffness, and functional capacity, and influenced several inflammatory markers (including IL-6, INF-ϒ, TNF-α, and C-reactive protein), particularly after two days of recovery from resistance exercise. The findings suggest that GingerT3® supplementation (125 mg/day, providing 12.5 mg/day of gingerols) may have beneficial effects on pain perception, functional capacity, and inflammatory markers in men and women with mild to moderate muscle and joint pain.

Broeckel J, Estes L, Leonard M, Dickerson BL, Gonzalez DE, Purpura M, Jäger R, Sowinski RJ, Rasmussen CJ, Kreider RB. Effects of Ginger Supplementation on Markers of Inflammation and Functional Capacity in Individuals with Mild to Moderate Joint Pain. Nutrients. 2025; 17(14):2365. https://doi.org/10.3390/nu17142365